Interested in Chimeron Bio for Your Career?
Apply to Our Open Positions

Roles at Chimeron offer an unparalleled experience to develop RNA-based drugs across multiple therapeutic areas. As an early employee, you will have direct insight into the Chimeron Bio vision and will be afforded the ability to make a broad impact on the future of the company. Our open positions include:

Eligible or interested applicants are encouraged to send their resumes or CV to careers@chimeron.com with the Position Title in the subject heading.


Principal Scientist / Manager – Preclinical Discovery, Oncology

Chimeron Bio, Inc. is a preclinical stage biotech company advancing a pipeline of novel RNA medicines across multiple therapeutic areas using its proprietary ChaESAR self-amplifying RNA delivery platform. We are excited about our innovative pipeline and are seeking a talented preclinical scientist with experience in oncology to join our growing team in Philadelphia, PA.

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Job Overview

We are seeking an experienced cancer immunologist to lead preclinical discovery and development programs in oncology. This is primarily a leadership role with ability to directly contribute to the discovery of novel therapeutics and vaccines. The ideal candidate will be experienced in oncology drug discovery programs and oversee cell biology, molecular biology and in-vivo efforts to support and progress the oncology portfolio. The role also includes leading a team of internal scientists (Ph.D and non-Ph.Ds) and interacting with external parties (CROs) to conduct program relevant in-vivo and in-vitro studies. In addition, the candidate will be able to analyze, interpret data and communicate effectively in program, lab, and executive meetings. The position offers strong growth potential, and an opportunity to work on a leading-edge RNA technology in a highly collaborative environment. As an early employee, the candidate will have direct insight into the company’s vision and will be afforded the ability to make a broad impact on the future of the Company. The candidate will be part of the pre-clinical oncology team and will report directly to the Chief Scientific Officer.

Expectations and Responsibilities:

  • Lead drug discovery programs in immuno-oncology from target validation to candidate selection and support non-clinical studies.
  • Design, execute, conduct studies and oversee study reports for the generation of preclinical data package to support IND-enabling studies.
  • Develop, communicate, and execute multi-disciplinary research strategies that will encompass target validation, biomarker identification and early development of novel therapeutics towards pipeline development.
  • Help build and manage a team of Ph.D. and non-Ph.D. lab scientists.
  • Develop a cohesive and nurturing team environment, based on respect, individual strengths, and empowerment.
  • Work alongside senior leaders of the Company to deliver set goals and objectives.
  • Be the point person for external collaborators and CROs to advance drug discovery programs.
  • Superior attention to detail when recording and analyzing data.
  • Maintain well-organized laboratory notebooks as per Company guidelines.
  • Participate in the production and quality control of RNA nanoparticle as it relates to the target.
  • Author briefing documents, study reports, assist with manuscripts, grant writing and preparation of presentations to stakeholders.
  • Stay current with respect to new and relevant technologies through reading scientific literature, etc.

Experience and Qualifications:

  • Ph.D. in Immunology or equivalent with 1-3 years of drug discovery experience in oncology, .
  • Strong scientific expertise in T cell biology and the immune system to treat cancer
  • Has in-depth knowledge of signaling pathways and immune cell function as it relates to immuno-oncology.
  • Understand and modulate T cell activity and other immune cell dysfunction within the tumor microenvironment
  • The ability to lead drug discovery programs, work in a team environment and collaborate across groups
  • Experienced in culturing primary human immune cells (T cells, NK cells and myeloid cells)
  • Hands-on experience with T-cell functional assays, antigen-specific T cell responses, T cell/NK-cell dependent cytotoxicity experiments, and T cell exhaustion
  • Experience with multiplex cytokine assays as well as intracellular cytokine staining by flow cytometry
  • Extensive experience with multi-color flow cytometry including panel design, staining fluency, compensation, and data analysis
  • Proficiency with use of Excel, GraphPad Prism, and Flowcytometry data analysis software such as FlowJo for data analysis
  • Strong interpersonal skills and demonstrated ability to be a team player and work in a fast-paced work environment
  • Prior experience in cell and gene therapy is a plus

Job Type: Full-Time

Work Remotely: No

COVID-19 considerations: Candidates must provide positive vaccination status.

Employment Authorization: Required

Benefits

Chimeron Bio is committed to providing a motivating work environment while simultaneously emphasizing a healthy work-life balance. We offer competitive compensation and benefits to foster professional and personal leadership and growth. Benefits include a competitive base pay, bonuses based on milestone targeted performance, 401k, stock options, paid employee medical, vision and dental insurance, long term disability and other fringe benefits

Qualified candidates are encouraged to send their resumes or CV to careers@chimeron.com with the Position Title in the subject heading.

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In-vivo Technician

Chimeron Bio, Corp. is a preclinical stage biotech company advancing a pipeline of novel RNA medicines across multiple therapeutic areas using its proprietary ChaESAR™ self-amplifying RNA delivery platform. We are excited about our innovative pipeline and are seeking a talented in vivo technician to join our growing team in Philadelphia, PA.

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Job Overview:

We are seeking an experienced in vivo technician to support our discovery team. This is a hands-on role with the ability to directly contribute to the discovery of novel therapeutics and vaccines. The ideal candidate will be extremely familiar with daily animal handling and tissue sampling and lead critical animal studies to determine efficacy, biodistribution, Pk/PD relationship amongst other assessments. The candidate will be an integral part of the drug discovery team and should be able to deliver with minimal supervision. This position offers the opportunity to work on a leading-edge RNA technology in a highly collaborative environment. This position reports to Senior Scientist and/or Discovery Program Leader.

Expectations and Responsibilities:

  • Ensure all animal studies are performed as per approved IACUC protocols
  • Provide the drug discovery team with high-quality animal care, monitoring and in-vivo study support
  • Support oncology team with in-vivo experiments in rodents that includes set-up, take down, establishing tumors, performing tumor measurements, measuring food intake and collecting body weights
  • Perform biodistribution studies and assess particle tropism using imaging systems such as the IVIS
  • Proficient in drug delivery via IV, SQ, IP, and IM injections
  • Proficient in blood collection via multiple routes (tail vein, submandibular, terminal bleeding)
  • Rodent euthanasia using CO2, anesthesia and/or approved physical methods
  • Collect tissues for Necropsy, and analysis (RNA, protein)
  • Be a team player, goal oriented and ensure all experiments are conducted in a timely manner
  • Will report directly to Sr. Scientist and/or Discovery program leader

Experience and Qualifications:

  • 1-2 years of hands-on experience in a laboratory, veterinary, or another animal-related setting required
  • Experienced in conducting in-vivo tumor experiment (tumor cell implantation, caliper measurements, bioluminescence imaging, standard mouse handling)
  • Experience with in-vivo imaging system is strongly preferred – Familiarity with the Animal Facility at the Wistar Institute in Philadelphia is a plus
  • Proficient with mouse handling and strong hands-on experience with animal injections: IV/SQ/IP/IM injections
  • Must have blood collection experience (tail vein, submandibular, terminal bleeding)
  • Experience with all activities related to animal necropsy and tissue collection
  • Cell culture experience required
  • Familiar with handling, processing, and analyzing tissue samples (i.e. RNA isolation, PCR, real time qPCR, Western Blotting)
  • Excellent written and verbal communication skills.
  • Attention to detail, maintenance of record of study design and conduct and study and data entry into electronic notebooks
  • Track record of study delivery on time
  • B.S. or a comparable degree preferred

Job Type: Full-Time 

Work Remotely: No 

COVID-19 considerations: Candidates must provide positive vaccination status. 

Employment Authorization: Required 

Benefits 

Chimeron Bio is committed to providing a motivating work environment while simultaneously emphasizing a healthy work-life balance. We offer competitive compensation and benefits to foster professional and personal leadership and growth. Benefits include a competitive base pay, bonuses based on milestone targeted performance, 401k, stock options, paid employee medical, vision and dental insurance, long term disability and other fringe benefits.

Qualified candidates are encouraged to send their resumes or CV to careers@chimeronbio.com with the Position Title in the subject heading.

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Associate Scientist/Scientist – Preclinical Discovery, Oncology

Chimeron Bio, Inc. is a preclinical stage biotech company advancing a pipeline of novel RNA medicines across multiple therapeutic areas using its proprietary ChaESAR self-amplifying RNA delivery platform. We are excited about our innovative pipeline and are seeking a talented preclinical scientist with experience in oncology to join our growing team in Philadelphia, PA.

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Job Overview:

We are seeking an experienced preclinical scientist to support preclinical discovery and development of our oncology programs. This is a hands-on, laboratory-focused role with ability to directly contribute to the discovery of novel therapeutics and vaccines. The ideal candidate will be experienced in oncology drug discovery programs and deploy cell culture, transfection, transduction and molecular biology techniques to conduct target validation and mechanism of action studies in support of the oncology portfolio. This includes the ability to perform functional cell population and characterization studies such as apoptosis and cell proliferation assays, and other techniques such as flow cytometry, ELISAs and fluorescence microscopy. In addition, the candidate will be able to analyze, interpret data and present in program and lab meetings, all with minimal supervision. This position offers strong growth potential, and an opportunity to work on a leading-edge RNA technology in a highly collaborative environment. As an early employee, the candidate will have direct insight into the company’s vision and will be afforded the ability to make a broad impact on the future of the Company. The candidate will be part of the pre-clinical oncology team and will report directly to the program leader.

Expectation and Responsibilities:

  • Development, design, execution, and conduct of cell-based assays to advance the oncology drug and vaccine portfolio
  • Execute cell/tissue preparation and conduct downstream molecular biology and biochemical assays, as well as cell population analyses
  • Conduct siRNA or overexpression studies using lipid or viral based methods for validation of target genes/proteins
  • Design and conduct experiments, analyze and interpret data with minimal supervision. Be able to use scientific graphing and statistical software as Graph Pad Prism to compile and share data
  • Maintain accurate electronic notebooks
  • Effectively present results and data in meetings, both internally and with external collaborators
  • The successful candidate must have the ability to accomplish the above tasks in a collaborative manner, with minimal supervision.
  • Stay current with respect to relevant scientific literature and technologies
  • Possess strong organizational and communication (verbal and written) skills, ability to work collaboratively with colleagues, self-motivated to learn and develop new skills, and ability to balance multiple simultaneous tasks

Experience and Qualifications:

  • BS degree in cell/molecular biology, biochemistry, or a related discipline with at least 5 years of relevant experience OR a Masters’ Degree with 3 years of relevant experience preferably obtained in an industry setting
  • Ideal candidate will have been part of a preclinical drug discovery/development program and have strong expertise in the development, design, and conduct of in vitro assays
  • Proficiency in mammalian cell culture, virus transduction, molecular biology techniques (qPCR, RT-PCR, etc), biochemical techniques (western blotting, ELISA, immunoassays), immunofluorescence microscopy, flow cytometry, and cell proliferation assays
  • Hands on experience with research instruments including QuantStudio RT-PCR and digital PCR machines, MSD (Meso Scale Discovery), fluorescence microscope and plate readers (such as Glo-Max), flow cytometers
  • Candidate must have experience with the use of graphing and statistical software such as GraphPad Prism
  • Strong interpersonal skills and demonstrated ability to be a team player and work in a fast-paced work environment
  • Prior experience in cell and gene therapy is a plus

Job Type: Full-Time 

Work Remotely: No 

COVID-19 considerations: Candidates must provide positive vaccination status. 

Employment Authorization: Required 

Benefits 

Chimeron Bio is committed to providing a motivating work environment while simultaneously emphasizing a healthy work-life balance. We offer competitive compensation and benefits to foster professional and personal leadership and growth.  Benefits include a competitive base pay, bonuses based on milestone targeted performance, 401k, stock options, paid employee medical, vision and dental insurance, long term disability and other fringe benefits 

Qualified candidates are encouraged to send their resumes or CV to careers@chimeronbio.com with the Position Title in the subject heading.

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Staff Accountant

Chimeron Bio, Inc. is a preclinical stage biotech company advancing a pipeline of novel RNA therapeutics across multiple therapeutic areas using its proprietary ChaESAR platform. We are seeking a talented individual to join our growing team in Philadelphia, PA. This position will allow for strong growth potential, and an opportunity to work in an energizing and highly collaborative environment. As an early employee, the candidate will have direct insight into the company’s vision and will be afforded the ability to make a broad impact on the future of the Company.

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Job Overview:

We are seeking a Staff Accountant to join our energetic and growing team. This role will be responsible for assisting the CFO with all activities related to the monthly accounting cycle as well as providing key support for all the Company’s Human Resource activities. The ideal candidate will be well organized, flexible, be able to work in a fast-paced environment with minimal supervision and enjoy the administrative challenges of supporting an early growth biotech company.

Expectations and Responsibilities are as follows:

  • Manage the purchase order process from creation to vendor invoice
  • Set up new vendors
  • Review, record and seek approval for all vendor and consultant invoices
  • Research and respond to vendor inquiries
  • Reconcile bank and credit card accounts.
  • Support the CFO with responsibilities such as updating spreadsheets and assistance with presentations.
  • Ensure all accounting and HR files are well organized
  • Prepare monthly payroll
  • Prepare, review and maintain each employee’s payroll deductions
  • Prepare / complete monthly 401k contribution reports
  • Assist with hiring and new employee onboarding
  • Enter / update benefits enrollment details for employees and maintain employee records in Company’s payroll system
  • Prepare, review and maintain each employee’s PTO banks
  • Support compliance with federal, state, and local regulations related to labor rules and employee file management
  • Assist with corporate activities such as team-building exercise, holiday parties, selection and delivery of corporate gifts
  • Other duties as assigned

Experience and Qualifications:

  • Bachelor’s Degree
  • Demonstrable working knowledge of basic accounting principles and at least 3 years of bookkeeping or accounting assistant experience
  • At least 2-year experience with processing payroll and other employee-related activities
  • High degree of accuracy and attention to detail.
  • Strong communication, prioritization, and organizational skills.
  • Ability to maintain confidentiality of sensitive information, interactions, and situations.
  • Ability to schedule, prioritize, meet deadlines, work independently with minimal supervision.
  • High degree of professionalism, strong work ethic and sense of responsibility
  • Proficiency with Microsoft Outlook, Microsoft Office (Sharepoint, Word, Excel and PowerPoint, Teams)
  • Excellent aptitude in using Quickbooks

Job Type: Full-Time 

Work Remotely: No 

COVID-19 considerations: Candidates must provide positive vaccination status. 

Employment Authorization: Required 

Benefits 

Chimeron Bio is committed to providing a motivating work environment while simultaneously emphasizing a healthy work-life balance. We offer competitive compensation and benefits to foster professional and personal leadership and growth. Benefits include a competitive base pay, bonuses based on milestone targeted performance, 401k, stock options, paid employee medical, vision and dental insurance, long term disability and other fringe benefits.

Qualified candidates are encouraged to send their resumes or CV to careers@chimeronbio.com with the Position Title in the subject heading.

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Why Chimeron Bio for Your Career?
Help Us Transform RNA Therapy for Patient Benefit

Chimeron Bio is committed to conducting the Highest Quality of cutting-edge Research and Development to better human lives with our transformative drugs.

We lead by incorporating Integrity, Transparency and Ethics in every decision we make.  We achieve by showing Respect for All. We grow by fostering Growth for All. We want everyone at Chimeron Bio to take Pride in the company they work for, the Value they add, the Impact they create and the Difference they make. We move Forward Together, as a team, each day and every day.

Explore Our Pipeline of saRNA-Based Medicines

See how Chimeron Bio is applying ChaESAR to develop therapeutics in our key focus areas of oncology, liver, and kidney-related genetic disorders and infectious diseases.

View Pipeline