Interested in Chimeron Bio for Your Career?
Apply to Our Open Positions

Roles at Chimeron offer an unparalleled experience to develop RNA-based drugs across multiple therapeutic areas. As an early employee, you will have direct insight into the Chimeron Bio vision and will be afforded the ability to make a broad impact on the future of the company. Explore our current openings below.

Eligible or interested applicants are encouraged to send their resumes or CV to careers@chimeron.com with the Position Title in the subject heading.


Sr. Manager/Director, Nanoparticle Production

In this position, the candidate will have managerial (70%) and hands-on lab responsibilities (30%) with the goal to assist and facilitate production of Chimeron Bio’s ChaESAR™ nanoparticle.  The position will transition to a fulltime leadership position overseeing the manufacturing and process development activities.

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Managerial responsibilities include:

  • Lead in-house nanoparticle production efforts and be single point of accountability for all aspects of production at Company designated CMOs for the effective and timely delivery of product.
  • Lead and oversee process development and method transfer to and from CRO partners and CMOs.
  • Work with senior management and external partners to develop and execute strategy for process development, optimization, scale-up and manufacturing of nanoparticles to support Chimeron Bio’s vaccine and therapeutic programs. 
  • Attract and retain talent and develop a high-performing team of PhD & non-PhD staff that will expand product engineering capability for effective and rapid design and development of novel nanoparticles to support the Chimeron Bio’s discovery efforts.
  • Review study design, execution plan, data, and study reports of all production and optimization work completed within the group.
  • Troubleshoot and resolve any technical issues in the production workstream.
  • Identify and implement novel technologies and superior approaches into Chimeron Bio’s manufacturing workstreams to improve speed and efficiency of product development.
  • Serve as the point of contact between Chimeron Bio’s drug discovery team and production team to design novel particles with improved potency and tropism profiles to support pipeline build.

Lab associated duties include:

  • Provide hands-on lab support to optimize the manufacturing process, conduct product efficacy and potency testing, optimize formulation, and implement process control.
  • Help with the cloning of new plasmids and engineering of novel nanoparticles for the vaccine and drug discovery team.
  • Develop new processes, or refine existing ones, and demonstrate improvement.
  • Determine methods to scale up the production process while maintaining or improving yields.  Suggests reducing costs to raw materials or components
  • Develop and validate parameters to ensure quality is maintained during scale-up and large-scale production.
  • Read and write technical reports and specifications, maintain detailed and appropriate records and draft SOPs.

Qualifications:

  • Ph.D. in biochemical engineering or biological sciences with 5-10 years of hands-on manufacturing and scale-up experience in upstream and downstream processes.
  • Solid foundation in the fundamentals of biochemical engineering and Virology.
  • Have strong people management and organizational skills; ability to prioritize and manage through complex processes/projects.
  • Experience in end-to-end planning, DoE, process characterization, and associated statistical analysis.
  • Working knowledge of cGMPs related to the manufacturing of gene therapy products (AVs, AAVs, VLPs, Lentiviruses or lipid-nanoparticles)
  • Experience with suspension and adherent cell line production and purification processes.  Use of size exclusion, TFF, ultracentrifugation and chromatography-based downstream process is preferred
  • Hands on experience with standard production and molecular analysis techniques such as mammalian cell culture, molecular cloning, qPCR, agarose gel electrophoresis, nucleotide extraction, protein detection by SDS-PAGE/western blotting, ELISA, plate-based assays, protein concentration assays etc.
  • Ability to influence peers and navigate multiple priorities to deliver key milestones on time while demonstrating strong collaborative spirit.
  • Ability to interpret data, define problems, establish facts, draw valid conclusions, and make data driven decisions.
  • Strong team player with excellent oral and written communication skills.
  • Experience of delivering in a fast-paced start-up environment is a strong plus.

Chimeron Bio, Inc. is a preclinical stage biotech company advancing a pipeline of novel RNA therapeutics across multiple therapeutic areas using its proprietary ChaESAR™ platform. We are seeking talented scientists to join our growing team in Philadelphia, PA. This position will allow for strong growth potential, and an opportunity to work in an energizing and highly collaborative environment. The role offers an unparalleled experience to develop RNA based drugs across multiple therapeutic areas. As an early employee, the candidate will have direct insight into the company’s vision and will be afforded the ability to make a broad impact on the future of the Company.

Chimeron Bio is committed to providing a motivating work environment while simultaneously emphasizing a healthy work-life balance. We offer competitive compensation and benefits to foster professional and personal leadership and growth.  Benefits include a competitive base pay, bonuses based on milestone targeted performance, 401k, stock options, paid employee medical, vision and dental insurance, PTO and other fringe benefits.

Qualified candidates are encouraged to send their resumes or CV to careers@chimeronbio.com with the Title in the subject heading.

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Associate Scientist/Scientist, Nanoparticle Production

This position is a combination of laboratory work and collaboration with external partners.

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Responsibilities and Expectations are as follows:

  • Participate in the production and quality control of RNA nanoparticles.
  • Design execute and conduct cell culture-based studies towards the optimization of novel drug design and method development for nanoparticle production.
  • Maintain accurate records and document all results and quality control parameters in laboratory notebooks as per Company guidelines.
  • Superior attention to detail when recording and analyzing data.
  • Project study report writing under the direction of supervisor.
  • Develop SOPs and protocols.
  • Stay current with new and relevant technologies through reading scientific literature and participation in meetings and conferences.
  • Effectively present results and data in meetings, both internally and with external collaborators.
  • Work efficiently with external partners and CROs/CMOs to advance research projects.
  • Work alongside colleagues and senior leaders to deliver set goals and objectives of the Company.
  • The successful candidate must have the ability to accomplish the above tasks in a collaborative manner, with minimal supervision.

Candidate Qualifications:

  • Bachelor of Science with 6-8 years of experience or Master of Science with 3-5 years of experience obtained at a Pharmaceutical, Biotech or CRO.
  • Must have been a part of a gene therapy production team and demonstrated strong expertise in formulation and manufacturing, CMC planning, assay development for process control.
  • Be highly proficient in mammalian tissue culture, DNA transfection methods, and virus titer evaluation.
  • Experience with routine in-process control methods such as, immunofluorescence microscopy, standard protein biochemistry techniques including western blot analysis and ELISA and molecular biology techniques including agarose gel electrophoresis and RT-PCR. Flow cytometry and/or HPLC experience is a plus.
  • Show aptitude for problem solving and possess strong verbal and written communication skills.
  • Ability to work and maintain strong relationships with management, peers and members of the team
  • Strong interpersonal skills and demonstrated ability to work in a fast-paced work environment
  • Experience in GLP laboratory operations and familiarity with regulatory compliance requirement is a plus.

Chimeron Bio, Inc. is a preclinical stage biotech company advancing a pipeline of novel RNA therapeutics across multiple therapeutic areas using its proprietary ChaESAR™ platform. We are seeking talented scientists to join our growing team in Philadelphia, PA. This position will allow for strong growth potential, and an opportunity to work in an energizing and highly collaborative environment. The role offers an unparalleled experience to develop RNA based drugs across multiple therapeutic areas. As an early employee, the candidate will have direct insight into the company’s vision and will be afforded the ability to make a broad impact on the future of the Company.

Chimeron Bio is committed to providing a motivating work environment while simultaneously emphasizing a healthy work-life balance. We offer competitive compensation and benefits to foster professional and personal leadership and growth.  Benefits include a competitive base pay, bonuses based on milestone targeted performance, 401k, stock options, paid employee medical, vision and dental insurance, PTO and other fringe benefits.

Qualified candidates are encouraged to send their resumes or CV to careers@chimeron.com with the Title in the subject heading.

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Sr. Scientist/Principal Scientist, Drug Discovery

This position is a combination of hands-on laboratory work and strategy development and execution. The successful candidate must work in a collaborative environment. The candidate will effectively lead preclinical projects with minimal supervision, manage interactions with CROs, academic collaborators, and external consultants, while contributing to the R&D strategy to help advance the Company’s technology and pipeline.

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Responsibilities and Expectations are as follows:

  • Develop multi-disciplinary research strategies that will encompass target validation, biomarker identification and early development to advance and build R&D pipeline.
  • Design, execute and conduct studies aimed at target validation, PK/PD and mechanism of action of candidates across therapeutic areas.
  • Be the point person for external collaborators and CROs with the aim to advance drug discovery programs across therapeutic areas.
  • Superior attention to detail when recording and analyzing data.
  • Maintain well-organized laboratory notebooks as per Company guidelines.
  • Assist with authoring manuscripts, grant applications, preparation of scientific blogs, and prepare data package for presentations to internal and external stakeholders.
  • Stay current with respect to new and relevant technologies through reading scientific literature, conference attendance etc.
  • Familiarity with in-vivo study design and data interpretation is a plus.

Candidate Qualifications:

  • Ph.D. in Cell and Molecular Biology, Virology or related scientific disciplines with 1-3 years of industry experience in preclinical drug discovery and development obtained at a Pharmaceutical, Biotech or CRO.  Master of Science with 3-5 years of experience are encouraged to apply.
  • Participated in pre-clinical programs and contributed to target discovery, target validation and/or candidate selection.
  • Presented new technologies and/or targets to stakeholders and obtained funding for advancing new drug discovery efforts.  .
  • Demonstrated ability to multitask, manage multiple stakeholder interactions and work effectively with team members in a fast-paced environment.
  • Possess strong expertise in in-vitro assay design and development, data interpretation and analysis
  • Proficient in mammalian tissue culture, immunofluorescence microscopy, standard molecular biology and protein biochemistry techniques including qRT-PCR, RNAi, agarose gel electrophoresis, western blot analysis, ELISA, and plate readers. Experience in molecular cloning and Flow Cytometry is a plus.
  • Possess excellent verbal and written communication skills.
  • Possess strong inter-personnel skill
  • In-vivo experience is a plus

Chimeron Bio, Inc. is a preclinical stage biotech company advancing a pipeline of novel RNA therapeutics across multiple therapeutic areas using its proprietary ChaESAR™ platform. We are seeking talented scientists to join our growing team in Philadelphia, PA. This position will allow for strong growth potential, and an opportunity to work in an energizing and highly collaborative environment. The role offers an unparalleled experience to develop RNA based drugs across multiple therapeutic areas. As an early employee, the candidate will have direct insight into the company’s vision and will be afforded the ability to make a broad impact on the future of the Company.

Chimeron Bio is committed to providing a motivating work environment while simultaneously emphasizing a healthy work-life balance. We offer competitive compensation and benefits to foster professional and personal leadership and growth. Benefits include a competitive base pay, bonuses based on milestone targeted performance, 401k, stock options, paid employee medical, vision and dental insurance, PTO and other fringe benefits.

Qualified candidates are encouraged to send their resumes or CV to careers@chimeron.com with the Title in the subject heading.

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Why Chimero Bio for Your Career?
Help Us Transform RNA Therapy for Patient Benefit

Chimeron Bio is committed to conducting the Highest Quality of cutting-edge Research and Development to better human lives with our transformative drugs.

We lead by incorporating Integrity, Transparency and Ethics in every decision we make.  We achieve by showing Respect for All. We grow by fostering Growth for All. We want everyone at Chimeron Bio to take Pride in the company they work for, the Value they add, the Impact they create and the Difference they make. We move Forward Together, as a team, each day and every day.

Explore Our Pipeline of saRNA-Based Medicines

See how Chimeron Bio is applying ChaESAR to develop therapeutics in our key focus areas of oncology, liver, and kidney-related genetic disorders and infectious diseases.

View Pipeline